Impact of lifestyle on the gut microbiota of healthy infants and their mothers – the ALADDIN birth cohort. Issue 3 (8th December 2014)

• Record Type: Journal Article
• Authors: Hesla, Helena M.; Stenius, Fredrik; Jäderlund, Lotta; Nelson, Ronald; Engstrand, Lars; Alm, Johan; Dicksved, Johan
• Is Part Of: FEMS microbiology ecology. Volume 90:Issue 3(2014)
• Page Start: 791
• Page End: 801
• Publication Date: 2014-12-08
• Subjects: 454-pyrosequencing -- anthroposophy -- Bifidobacterium -- breastfeeding -- caesarean section -- gut microbiota; Microbial ecology -- Periodicals; Microbiology -- Periodicals; 579.17
• DOI: 10.1111/1574-6941.12434
• Languages: English
• ISSNs: 0168-6496

Abstract

Abstract: An anthroposophic lifestyle, which has been associated with reduced allergy risk in children, has several characteristics that could influence gut microbiota. This study aimed to investigate the impact of anthroposophic lifestyle as well as specific early life exposures on the gut microbiota. In total, 665 stool samples from 128 mother–infant pairs from the ALADDIN birth cohort study were included. Samples collected from infants at ages 6 days, 3 weeks, 2 months and 6 months, and from their mothers before and after delivery, respectively, were analyzed using 454-pyrosequencing. Information regarding lifestyle exposures was collected prospectively through interviews and questionnaires. Six-month-old infants in anthroposophic families had a significantly higher abundance of Bifidobacterium and lower abundances of Bacteroides and Veillonella . Caesarean section and breastfeeding had a significant impact on the microbiota: caesarean section was primarily associated with delayed colonization of Bifidobacterium and Bacteroides, whereas breastfed children had a higher relative abundance of Bifidobacterium and a lower abundance of Clostridiales . However, despite large differences in lifestyle exposures, we determined no significant differences in the gut microbiota between the anthroposophic and non-anthroposophic mothers or their infants' before 6 months of age. Abstract : This study provides new information on the impact of early life exposures on the infant microbiota, which in turn has been associated with later health outcomes such as allergy. Abstract :