Biological washout effect in in-beam PET: animal studies. (October 2020)

• Record Type: Journal Article
• Authors: Toramatsu, C; Mohammadi, A; Wakizaka, H; Seki, C; Nishikido, F; Sato, S; Kanno, I; Takahashi, M; Karasawa, K; Hirano, Y; Yamaya, T
• Is Part Of: Journal of physics. Volume 1662(2020)
• Publication Date: 2020-10
• Subjects: Physics -- Congresses; 530.5
• DOI: 10.1088/1742-6596/1662/1/012032
• Languages: English
• ISSNs: 1742-6588

Abstract

Abstract: Positron emission tomography (PET) is a practical tool for range verification of hadron therapy. As well, the quantitative washout of the positron emitters has a potential usefulness as a diagnostic index, but the modelling for this has not been established. In this study, we measured washout rates of rabbit brain and performed kinetic analysis to explore the washout mechanism. Six rabbit brains were irradiated by 11 C and 15 O ion beams, and dynamic PET scan was performed using our original depth of interest (DOI)-PET prototype. The washout rate was obtained based on the two-compartment model, where efflux from tissue to blood (k2 ), influx (k3 ) and efflux (k4 ) from the first to second compartments in tissue were evaluated. The observed k2, k3 and k4 of 11 C were 0.086, 0.137 and 0.007 min −1, and those of 15 O were 0.502, 0.360 and 0.007 min −1, respectively. It was suggested permeability of a molecule containing 11 C atoms might be regulated by a transporter. The k2 of 15 O was comparable with 15 O-water. This study provides basic data for modelling of the washout effect.