Advancement of microdosimetric kinetic model in heavy-ion radiotherapy. (October 2020)

• Record Type: Journal Article
• Authors: Inaniwa, T
• Is Part Of: Journal of physics. Volume 1662(2020)
• Publication Date: 2020-10
• Subjects: Physics -- Congresses; 530.5
• DOI: 10.1088/1742-6596/1662/1/012014
• Languages: English
• ISSNs: 1742-6588

Abstract

Abstract: To date, more than 11, 000 cancer patients have been treated with therapeutic carbon-ion beams at the National Institute of Radiological Sciences (NIRS). In the treatment planning system, the biological effectiveness of the therapeutic carbon-ion beams has been predicted based on the microdosimetric kinetic (MK) model. The MK model has a variety of applications. For instance, it can be used to predict the biological effectiveness of therapeutic carbon-ion beams under protracted irradiations as well as under hypoxic conditions. Recently, we have updated the MK model to a stochastic microdosimetric kinetic (SMK) model for a new research project about hypo-fractionated multi-ion radiotherapy, referred to as a "Quantum Scalpel". This report overviews advancement of the MK model in heavy-ion radiotherapy.