Heterogeneity of 68Ga-PSMA PET/CT Uptake in Fibrous Dysplasia. (October 2019)

• Record Type: Journal Article
• Authors: Plouznikoff, Nicolas; Garcia, Camilo; Artigas, Carlos; Entezari, Kim; Flamen, Patrick
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 10(2019)
• Publication Date: 2019-10
• Subjects: 68Ga-PSMA -- pitfall -- fibrous dysplasia -- heterogeneity -- prostate cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002609
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Fibrous dysplasia is an uncommon benign bone pathology with only rare potential for malignant transformation. We describe the heterogeneous uptake of fibrous dysplasia of a whole rib on 68 Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT. 68 Ga-PSMA binds to PSMA-expressing prostate cancer cells, but it can also bind to the neovasculature of various solid tumors, as well as to some benign lesions. 68 Ga-PSMA expression in fibrous dysplasia should not automatically be equated with malignant transformation or confused with prostate cancer metastases.