Reprogramming of antibiotics to combat antimicrobial resistance. Issue 11 (10th August 2020)

• Record Type: Journal Article
• Authors: Dubey, Kashyap K.; Indu, ; Sharma, Manisha
• Is Part Of: Archiv der Pharmazie. Volume 353:Issue 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-10
• Subjects: adjuvants -- antibiotic resistance -- antimicrobial resistance -- drug repurposing -- multidrug resistance; Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.202000168
• Languages: English
• ISSNs: 0365-6233

Abstract

Abstract: This review outlines a literature‐based approach with illustrative examples of drug repurposing (one molecule, multiple targets), which will be useful in tackling the problem of antimicrobial resistance (AMR). Globally, the demands for new drugs have increased due to multidrug‐resistant pathogens and emerging viruses. Keeping these facts in view, drug repurposing started for utilization of a drug in a different way from a preexisting drug, which reduces the time and cost of development of a new drug. Repurposing increases the potency of a drug and reduces its toxicity level, as it is required in lower amounts, supporting the utilization of the drug as a new therapeutic option. This will be further explored to highlight the application in AMR. Abstract : This review provides illustrative examples of drug repurposing (one molecule, multiple targets), which will be useful in tackling the antimicrobial resistance (AMR) problem. Repurposing increases the potency of a drug and reduces its toxicity level. This will be further explored to highlight the application in AMR.