The Effect of Stroke on Middle Cerebral Artery Blood Flow Velocity Dynamics During Exercise. Issue 4 (October 2019)
- Record Type:
- Journal Article
- Title:
- The Effect of Stroke on Middle Cerebral Artery Blood Flow Velocity Dynamics During Exercise. Issue 4 (October 2019)
- Main Title:
- The Effect of Stroke on Middle Cerebral Artery Blood Flow Velocity Dynamics During Exercise
- Authors:
- Kempf, Katie S.
Whitaker, Alicen A.
Lui, Yumei
Witte, Emily
Perdomo, Sophy J.
Ward, Jaimie L.
Eickmeyer, Sarah
Ledbetter, Luke
Abraham, Michael
Billinger, Sandra A. - Abstract:
- Abstract : Background and Purpose: Previous work demonstrates that older adults have a lower response in the middle cerebral artery velocity (MCAv) to an acute bout of moderate-intensity exercise when compared with young adults. However, no information exists regarding MCAv response to exercise after stroke. We tested whether MCAv response to an acute bout of moderate-intensity exercise differed between participants 3 months after stroke and an age- and sex-matched control group of older adults (CON). A secondary objective was to compare MCAv response between the stroke- and non-stroke-affected MCAv. Methods: Using transcranial Doppler ultrasound, we recorded MCAv during a 90-second baseline (BL) followed by a 6-minute moderate-intensity exercise bout using a recumbent stepper. Heart rate (HR), end-tidal CO2 (PET CO2 ), and beat-to-beat mean arterial blood pressure (MAP) were additional variables of interest. The MCAv response measures included BL, peak response amplitude (Amp), time delay (TD), and time constant (τ). Results: The Amp was significantly lower in the stroke-affected MCAv compared with CON ( P < 0.01) and in the nonaffected MCAv compared with CON ( P = 0.03). No between-group differences were found between TD and τ. No significant differences were found during exercise for PET CO2 and MAP while HR was lower in participants with stroke ( P < 0.01). Within the group of participants with stroke, no differences were found between the stroke-affected andAbstract : Background and Purpose: Previous work demonstrates that older adults have a lower response in the middle cerebral artery velocity (MCAv) to an acute bout of moderate-intensity exercise when compared with young adults. However, no information exists regarding MCAv response to exercise after stroke. We tested whether MCAv response to an acute bout of moderate-intensity exercise differed between participants 3 months after stroke and an age- and sex-matched control group of older adults (CON). A secondary objective was to compare MCAv response between the stroke- and non-stroke-affected MCAv. Methods: Using transcranial Doppler ultrasound, we recorded MCAv during a 90-second baseline (BL) followed by a 6-minute moderate-intensity exercise bout using a recumbent stepper. Heart rate (HR), end-tidal CO2 (PET CO2 ), and beat-to-beat mean arterial blood pressure (MAP) were additional variables of interest. The MCAv response measures included BL, peak response amplitude (Amp), time delay (TD), and time constant (τ). Results: The Amp was significantly lower in the stroke-affected MCAv compared with CON ( P < 0.01) and in the nonaffected MCAv compared with CON ( P = 0.03). No between-group differences were found between TD and τ. No significant differences were found during exercise for PET CO2 and MAP while HR was lower in participants with stroke ( P < 0.01). Within the group of participants with stroke, no differences were found between the stroke-affected and non-stroke-affected sides for any measures. Discussion and Conclusions: Resolution of the dynamic response profile has the potential to increase our understanding of the cerebrovascular control mechanisms and test cerebrovascular response to physical therapy–driven interventions such as exercise. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A284 ). Abstract : Supplemental Digital Content is Available in the Text. … (more)
- Is Part Of:
- Journal of neurologic physical therapy. Volume 43:Issue 4(2019:Oct.)
- Journal:
- Journal of neurologic physical therapy
- Issue:
- Volume 43:Issue 4(2019:Oct.)
- Issue Display:
- Volume 43, Issue 4 (2019)
- Year:
- 2019
- Volume:
- 43
- Issue:
- 4
- Issue Sort Value:
- 2019-0043-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-10
- Subjects:
- blood flow -- brain -- exercise -- stroke -- vascular
Nervous system -- Diseases -- Physical therapy -- Periodicals
Nervous system -- Diseases -- Treatment -- Periodicals
616.80462 - Journal URLs:
- http://gateway.ovid.com/ovidweb.cgi?T=JS&MODE=ovid&NEWS=n&PAGE=toc&D=ovft&AN=01253086-000000000-00000 \9 20130211 ↗
http://journals.lww.com/jnpt/pages/default.aspx ↗
http://www.jnpt.org/jnpt/index.cfm ↗
http://journals.lww.com ↗ - DOI:
- 10.1097/NPT.0000000000000289 ↗
- Languages:
- English
- ISSNs:
- 1557-0576
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5021.553250
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 14786.xml