Isolated Muscular Sarcoidosis Revealed by Hypercalcemia and 18F-FDG PET/CT. (October 2019)

• Record Type: Journal Article
• Authors: Dhomps, Anthony; Foret, Thibault; Streichenberger, Nathalie; Skanjeti, Andrea; Tordo, Jeremie
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 10(2019)
• Publication Date: 2019-10
• Subjects: FDG -- PET/CT -- myositis -- muscular sarcoidosis -- hypercalcemia; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002678
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 43-year-old woman, with previous history of renal lithiasis, was admitted on an emergency for severe hypercalcemia fortuitously discovered in a context of rapidly progressive kidney failure. An 18 F-FDG PET/CT performed to rule out underlying malignancy revealed an intense diffuse and isolated muscular FDG uptake with fascia infiltration on the CT finding. A muscular biopsy was performed and demonstrated a non-necrosing granuloma with multinucleated giant cells consistent with muscular sarcoidosis. A corticotherapy was started with a rapid normalization of serum calcium level. The follow-up 18 F-FDG PET/CT 4 months later showed a complete response of the sarcoidosis myositis.