Secondary Cutaneous Dissemination of Peripheral T‐Cell Lymphoma With T-Follicular Helper Phenotype as a Patient's Fourth Primary Malignancy. (October 2019)

• Record Type: Journal Article
• Authors: Beksaç, Burcu; Acar, Emine M.; Ilter, Nilsel; Ertunc, Onur; Akyurek, Nalan
• Is Part Of: American journal of dermatopathology. Volume 41:Number 10(2019)
• Publication Date: 2019-10
• Subjects: peripheral T-cell lymphoma -- TFH phenotype -- cutaneous -- multiple malignancies; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000001420
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Peripheral T-cell lymphomas expressing follicular helper T-cell (TFH ) markers have recently been identified. Although this type of lymphomas consist of malignant proliferation of T‐cells, they may also exhibit B‐cell clonality. We report a case of a 72‐year‐old woman with multiple erythematous to violaceous nonscaling plaques and tumors on her trunk. Histopathological analysis revealed a dense infiltration of medium‐to‐large–sized atypical cells throughout the entire dermis. The result of immunohistochemical analysis showed that the infiltrating T-cells expressed programmed death‐1 (PD‐1), CD10, Bcl-6, CD3, CD4, CD2, and CD5. The infiltrate also contained scattered atypical large B‐cells. Based on the clinical appearance and the histopathological findings, we diagnosed the patient with secondary cutaneous dissemination of peripheral T‐cell lymphoma with expression of a T-follicular helper phenotype.