Do chick and rodent neuron biosensors function similarly?. Issue 5 (31st March 2020)

• Record Type: Journal Article
• Authors: Kuang, Serena Y.; Yang, Xiaoqi; Wei, Lina; Huang, Ting; Wang, Zhonghai; Xi, Tingfei; Gao, Bruce Z.
• Is Part Of: Medical devices & sensors. Volume 3:Issue 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-31
• Subjects: chick neurons -- comparative biology/physiology -- concentration–response curve -- microelectrode array -- spontaneous spiking activity; Medical instruments and apparatus -- Periodicals; Biomedical engineering -- Periodicals; Electronic journals; Periodicals; 610.28
• DOI: 10.1002/mds3.10078
• Languages: English
• ISSNs: 2573-802X

Abstract

Abstract: A growing number of research papers report similarities in cell types, neuronal connections and information‐processing principles between chick and rodent cortical tissues, which have very different architectures. This paper extends these comparisons beyond the cortical tissues. Using microelectrode array technology, we report three remarkable functional similarities between our original chick data and rodent data from the literature: (a) the pattern of spontaneous spiking activity from chick spinal cord neuron biosensors is very similar to that of rodent spinal cord neuron biosensors (i.e. rodent counterparts). (b) The spontaneous spiking activity pattern of the chick forebrain neuron biosensors is very similar to that of the rodent cortical neuron biosensors, but chick forebrain neuron biosensors contain not only cortical neurons, but also diencephalic neurons. In other words, chick forebrain neuron biosensors cannot be considered the counterparts of rodent cortical neuron biosensors. (c) Chick forebrain neuron biosensors respond to several classical neuroactive agents in a way similar to rodent cortical neuron biosensors as reflected in their agent‐specific concentration–response curves and their values of EC50 (the effective concentration that causes 50% of the maximal effect of an agent). These preliminary findings provide both direct and indirect support for a positive answer to the big research question in the title: 'Do chick and rodent neuron biosensors function similarly' if the sources of the neurons are homologous between chick and rodent? Our findings are of particular value to comparative biology/physiology, pharmacology, neurotoxicology and bioengineering and to research on the more cost‐effective extended application of chick neuron biosensors.