In vitro activities of antifungal drugs against a large collection of Trichophyton tonsurans isolated from wrestlers. Issue 12 (13th September 2020)

• Record Type: Journal Article
• Authors: Kermani, Firoozeh; Javidnia, Javad; Hedayati, Mohammad T.; Abastabar, Mahdi; Haghani, Iman; Didehdar, Mojtaba; Fami Zaghrami, Mahmoud; Shokohi, Tahereh
• Is Part Of: Mycoses. Volume 63:Issue 12(2020)
• Page Start: 1321
• Page End: 1330
• Publication Date: 2020-09-13
• Subjects: dermatophytosis -- in vitro antifungal susceptibility testing -- Tinea gladiatorum -- Trichophyton tonsurans; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.13172
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: Background: Trichophyton tonsurans is the most common agent causing tinea gladiatorum in wrestlers, and limited data on susceptibility profiles of Trichophyton tonsurans are available. Objectives: We aimed to assess the in vitro activity of the common antifungal drug against a large collection of T tonsurans . Materials/Methods: The in vitro activities to eight common antifungal drugs (sertaconazole, itraconazole, clotrimazole, fluconazole, butenafine, tolnaftate, terbinafine and griseofulvin) against 128 clinical isolates of T tonsurans strains, obtained from wrestlers with dermatophytosis, were performed according to CLSI M38‐A2 broth microdilution document. Results: The geometric mean minimum inhibitory concentration was the lowest for tolnaftate (0.022 µg/mL), followed by itraconazole (0.026 µg/mL), terbinafine (0.033 µg/mL), butenafine (0.088 µg/mL), griseofulvin (0.566 µg/mL), sertaconazole (2.875 µg/mL), clotrimazole (3.419 µg/mL) and fluconazole (12.540 µg/mL). Conclusions: Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs against T tonsurans and fluconazole had the least effect.