Chemical and activity investigation on metabolites produced by an endophytic fungi Psathyrella candolleana from the seed of Ginkgo biloba. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Pan, Yun; Zheng, Weihong; Yang, Shengli
• Is Part Of: Natural product research. Volume 34:Issue 21(2020)
• Page Start: 3130
• Page End: 3133
• Publication Date: 2020-11-01
• Subjects: Ginkgo biloba -- endophytic fungi -- Psathyrella candolleana; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1607335
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: An endophytic fungus that can produce flavonoids was isolated from the seed of Ginkgo biloba cultured in Czapek-Dox medium and chromatographic separation of the ethyl acetate extract of the broth and mycelium led to the isolation of ergosterol (1), 2′-hydroxychalcone (2), myristic acid (3), cis-9-octadecenoamide (4), quercetin (5), carboxybenzene (6), uracil (7) and nicotinamide (8). This study is the first to report of the isolation of the endophytic fungus Psathyrella candolleana from the seed of Ginkgo biloba with complete assignments of 1–8. Compound (5) exhibited strong antioxidant activity of diphenyl picryl hydrazinyl (CL50 14.538 μg/mg) and compounds (5), (6) and (8) have antibacterial activity against Staphylococcus aureus (MIC 0.3906, 0.7812 and 6.25 mg/mL). Graphical Abstract: