Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Wang, Bang-Yan; Yang, Ya-Bin; Yang, Xue-Qiong; Zhu, Chen-Hao; Yang, Shuang; Xu, Ting-Ting; Wang, Xue-Yin; Tan, Ning-Hua; Zhou, Hao; Ding, Zhong-Tao
• Is Part Of: Natural product research. Volume 34:Issue 21(2020)
• Page Start: 3101
• Page End: 3107
• Publication Date: 2020-11-01
• Subjects: Metabolite -- Daldinia eschscholzii -- red ginseng -- medium induction -- bioactivity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1610751
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Red ginseng (RG) is one of the most popular herbal medicines and used as a dietary supplement in recent years. The bioactive ingredient in RG can induce the production of novel microbial metabolite from fermented RG. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Daldinia eschscholzii JC-15 cultured in red ginseng medium led to the isolation of an unprecedented benzopyran-naphthalene hybrid, daldinsin (1 ) and a new lactone (2 ). In this research, a new lactone, 8-hydroxylhelicascolide A (2 ) instead of helicascolide A was produced by the D. eschscholzii JC-15 induced by the red ginseng medium. Compound 1 showed anti-acetylcholinesterase activity with the inhibition ratio of 38.8% at 50 μM. Compound 2 indicated antimicrobial activities against Fusarium Solani, F. oxysporum, and Escherichia coli with MICs at 128 μg/mL. RG is therefore a promising activator in production of novel microbial metabolite. Graphical Abstract: