A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Adelakun, Tiwalade A.; Ding, Xiao; Ombati, Rose M.; Zhao, Ning-Dong; Obodozie-Ofoegbu, Obiageri O.; Di, Ying-Tong; Zhang, Yu; Hao, Xiao-Jiang
• Is Part Of: Natural product research. Volume 34:Issue 21(2020)
• Page Start: 3027
• Page End: 3035
• Publication Date: 2020-11-01
• Subjects: Euphorbia fischeriana Steud -- highly oxygenated abietanes -- phorbol esters -- lysosomal biogenesis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1607331
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Twenty-two diterpenoids (1–22 ), including two new ones (1, a tigliane-type diterpenoid and 8, an abietane-type diterpenoid) were isolated from the roots of Euphorbia fischeriana Steud. Among them, compounds 4, 7, 12, 14–16, 19–21 are isolated from this plant for the first time. Their structures were elucidated through extensive 1D, 2D NMR and the HRESIMS data. The 13 C data of 4 is hereby presented for the first time. The macrocyclic diterpenes 1 and 2 showed marked enhancement of lysosomal biosynthesis after evaluation using lysoTracker staining method. Graphical Abstract: