Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies. Issue 42 (19th October 2020)

• Record Type: Journal Article
• Authors: Guidolin, Nicol; Travagin, Fabio; Giovenzana, Giovanni B.; Vágner, Adrienn; Lotti, Sophia; Chianale, Federica; Brücher, Ernő; Maisano, Federico; Kirchin, Miles A.; Tedoldi, Fabio; Giorgini, Alice; Colombo Serra, Sonia; Baranyai, Zsolt
• Is Part Of: Dalton transactions. Volume 49:Issue 42(2020)
• Page Start: 14863
• Page End: 14870
• Publication Date: 2020-10-19
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt03314f
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Collagen can form electrostatic interactions and hydrogen-bonds with macrocyclic Gd III -complexes which might explain their different in vivo retention. Abstract : The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of Gd III -complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.