Fluorescent nanorods based on 9, 10-distyrylanthracene (DSA) derivatives for efficient and long-term bioimaging. Issue 41 (1st October 2020)

• Record Type: Journal Article
• Authors: Han, Wenkun; Du, Yangyang; Song, Meiyu; Sun, Kaiju; Xu, Bin; Yan, Fei; Tian, Wenjing
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 41(2020)
• Page Start: 9544
• Page End: 9554
• Publication Date: 2020-10-01
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb02883h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Fluorescent nanoparticles based on 9, 10-distyrylanthracene (DSA) derivatives (4, 4′-((1 E, 1′ E )-anthracene-9, 10-diylbis(ethene-2, 1-diyl))bis( N, N -dimethylaniline) (NDSA) and 4, 4′-((1 E, 1′ E )-anthracene-9, 10-diylbis(ethene-2, 1-diyl))dibenzonitrile (CNDSA)) were prepared using an ultrasound aided nanoprecipitation method. Abstract : Fluorescent nanoparticles based on 9, 10-distyrylanthracene (DSA) derivatives (4, 4′-((1 E, 1′ E )-anthracene-9, 10-diylbis(ethene-2, 1-diyl))bis( N, N -dimethylaniline) (NDSA) and 4, 4′-((1 E, 1′ E )-anthracene-9, 10-diylbis(ethene-2, 1-diyl))dibenzonitrile (CNDSA)) were prepared using an ultrasound aided nanoprecipitation method. The morphologies of the fluorescent nanoparticles could be controlled by adjusting the external ultrasonication time. NDSA or CNDSA could form spherical nanodots (NDSA NDs, CNDSA NDs) in a THF–H2 O mixture with an 80% or 70% water fraction when the ultrasonication time was 30 s. When the ultrasonication time was prolonged to 10 min, NDSA and CNDSA could assemble into nanorods (NDSA NRs, CNDSA NRs). Meanwhile, the sizes of NDSA NRs and CNDSA NRs could be controlled by adjusting the water content in the mixture. As the water fraction was increased from 60% to 80%, the sizes of NDSA and CNDSA nanorods or nanodots reduced from 238.4 nm to 140.3 nm, and 482 nm to 198.4 nm, respectively. When the water fraction was up to 90%, irregular morphologies of NDSA and CNDSA could be observed. The nanoparticles exhibited intense fluorescence emission, good anti-photobleaching properties, as well as excellent stability and biocompatibility. In vitro cell imaging experiments indicated that the nanorods prepared by this simple method had the potential to be used for efficient and noninvasive long-term bioimaging.