Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1. Issue 41 (15th October 2020)

• Record Type: Journal Article
• Authors: Kim, Jung Wha; Kwon, Yun; Bang, Sunghee; Kwon, Ha Eun; Park, Sunwoo; Lee, Yeonhee; Deyrup, Stephen T.; Song, Gwonhwa; Lee, Dongho; Joo, Hwang-Soo; Shim, Sang Hee
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 41(2020)
• Page Start: 8443
• Page End: 8449
• Publication Date: 2020-10-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01851a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Two new unusual angucyclinones (1 and 2 ) with intramolecular ether bridges with two known ones (3 and 4 ) were isolated from Streptomyces bulli . Compound 3 exhibited potent anti-proliferative and anti-virulent activities against MRSA. Abstract : Two new unique angucyclinones (1 and 2 ) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4 ). The MS 2 -based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells.