A practical ortho-acylation of aryl iodides enabled by moisture-insensitive activated esters via palladium/norbornene catalysis. Issue 21 (29th September 2020)

• Record Type: Journal Article
• Authors: Feng, Yunxia; Wang, Yangyang; Zhao, Shen; Zhang, Dao-Peng; Li, Xinjin; Liu, Hui; Dong, Yunhui; Sun, Feng-Gang
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 21(2020)
• Page Start: 3420
• Page End: 3426
• Publication Date: 2020-09-29
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00982b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Herein reported is a practical Catellani-type ortho -acylation of aryl iodides enabled by employing moisture-insensitive esters as the electrophile via C(O)–O bond cleavage. Abstract : A novel ortho -arene C–H acylation of aryl iodides catalyzed by the palladium/norbornene cooperative system by employing triazine esters has been developed, leading to the synthesis of polysubstituted aryl ketones. This ortho -acylation even proceeds smoothly in water. Preliminary mechanistic experiments indicate that the strong electron-withdrawing ability and coordination chemistry of triazine play crucial roles in this transformation.