Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient. Issue 5 (23rd May 2020)

• Record Type: Journal Article
• Authors: Assaf, Ady; Faure, Emmanuel; Sermet, Kevin; Loridant, Severine; Leroy, Jordan; Goeminne, Celine; Dozier, Aurelie; Chopin, Marie‐Charlotte; Panaget, Sophie; Faure, Karine; Vuotto, Fanny
• Is Part Of: Transplant infectious disease. Volume 22:Issue 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-23
• Subjects: aspergillosis -- heart transplantation -- isavuconazole -- sternal osteomyelitis; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13313
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: A 65‐year‐old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second‐line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole‐based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.