A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication. Issue 4 (7th June 2016)

• Record Type: Journal Article
• Authors: Nepovimova, E.; Korabecny, J.; Dolezal, R.; Nguyen, T. D.; Jun, D.; Soukup, O.; Pasdiorova, M.; Jost, P.; Muckova, L.; Malinak, D.; Gorecki, L.; Musilek, K.; Kuca, Kamil
• Is Part Of: Toxicology research. Volume 5:Issue 4(2016:Jul.)
• Page Start: 1012
• Page End: 1016
• Publication Date: 2016-06-07
• Subjects: Toxicology -- Periodicals; 615.9005
• DOI: 10.1039/c6tx00130k
• Languages: English
• ISSNs: 2045-452X

Abstract

Abstract : A novel hybrid able to protect organophosphate-inhibited AChE as well as to reactivate it. Abstract : Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.