Anaplastic large cell lymphoma as a posttransplant lymphoproliferative disorder in a renal transplant patient: A case report. Issue 1 (10th July 2020)

• Record Type: Journal Article
• Authors: Alabdulbaqi, Manar; Toupin, Melissa; Berardi, Philip; McCurdy, Arleigh
• Is Part Of: EJHaem. Volume 1:Issue 1(2020)
• Page Start: 364
• Page End: 367
• Publication Date: 2020-07-10
• Subjects: Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.13
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: We report a case of a 45‐year‐old female who developed an ALK‐positive anaplastic large cell lymphoma (ALCL) 9 years after renal transplant. The patient underwent a cadaveric renal transplant for diabetic nephropathy, and presented 9 years later with fever and multiorgan dysfunction. The initial CT scans showed multiple enlarged supra‐ and infradiaphrgamatic lymph nodes. A CT‐guided core needle biopsy of a retroperitoneal lymph node revealed ALK positive ALCL. She received six cycles of cyclophosphamide, adriamycin, vincristine, etoposide, and prednisone, and has been in remission for over 3 years. Monomorphic T‐cell posttransplant lymphoproliferative disorder (PTLD) is an established but rare entity of PTLD and generally carries poor prognosis. This is a case report of a late PTLD with pathology reporting an aggressive T‐cell lymphoma that has been successfully treated with multiagent chemotherapy.