Gadoxetate disodium-enhanced MRI: Assessment of arterial phase artifacts and hepatobiliary uptake in a large series. Issue 132 (November 2020)

• Record Type: Journal Article
• Authors: Vietti Violi, Naik; Argiriadi, Pamela; Rosen, Ally; Cherny, Mathew; Weiss, Amanda; Hernandez-Meza, Gabriela; Babb, James S.; Kihira, Shingo; Lewis, Sara; Taouli, Bachir
• Is Part Of: European journal of radiology. Issue 132(2020)
• Publication Date: 2020-11
• Subjects: AP arterial phase -- BMI body mass index -- ECA extracellular contrast agents -- HBP hepatobiliary phase -- IQR interquartile range -- PV portal vein -- PVP portal venous phase -- TSM transient severe motion; MRI -- Gadoxetate disodium -- Transient severe motion -- Hepatobiliary phase; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2020.109313
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: TSM was found in 12.1 % of MRI performed with gadoxetate disodium. TSM was poorly associated to clinical factors and not associated to MRI parameters. TSM and limited hepatobiliary phase contrast uptake were rarely associated. Abstract: Purpose: To report the quality of gadoxetate disodium MRI in a large series by assessing the prevalence of: 1) arterial phase (AP) artifacts and its predictive factors, 2) decreased hepatic contrast uptake during the hepatobiliary phase (HBP). Methods: This retrospective single center study included 851 patients (M/F:537/314, mean age: 63y) with gadoxetate disodium MRI. The MRI protocol included unenhanced, dual arterial [early and late arterial phases (AP)], portal venous, transitional and hepatobiliary phases. Three radiologists graded dynamic images using a 5-scale score (1: no motion, 5: severe, nondiagnostic) for assessment of transient severe motion (TSM, defined as a score ≥4 during at least one AP with a score ≤3 during other phases). HBP uptake was assessed using a 3-scale score (based on portal vein/hepatic signal). The association between demographic, clinical and acquisition parameters with TSM was tested in uni- and multivariate logistic regression. Results: TSM was observed in 103/851 patients (12.1 %): 83 (9.8 %) in one AP and 20 (2.3 %) in both APs. A score of 5 (nondiagnostic) was assigned in 7 patients in one AP (0.8 %) and none in both. Presence of TSM was significantly associated with age (p = 0.002) and liver disease (p = 0.033) in univariate but not in multivariate analysis (p > 0.05). No association was found between acquisition parameters and TSM occurrence. Limited or severely limited HBP contrast uptake was observed in 87 patients (10.2 %), and TSM was never associated with severely limited HBP contrast uptake. Conclusion: TSM was present in approximately 12 % of gadoxetate disodium MRIs, rarely on both APs (2.3 %), and was poorly predicted. TSM was never associated with severely limited HBP contrast uptake.