(±)-Neonardochinone A, a pair of enantiomeric neoligans from Nardostachys chinensis with their anti-Alzheimer's disease activities. (October 2020)

• Record Type: Journal Article
• Authors: Wu, Pei-Qian; Li, Bing; Yu, Yi-Fan; Zhao, Ye; Yu, Chun-Xue; Zhi, De-Juan; Qi, Feng-Ming; Su, Pan-Jie; Wang, Ru-Yue; Fei, Dong-Qing; Zhang, Zhan-Xin
• Is Part Of: Phytochemistry letters. Volume 39(2020)
• Page Start: 39
• Page End: 42
• Publication Date: 2020-10
• Subjects: Nardostachys chinensis -- (±)-Neonardochinone A -- Enantiomeric separation -- Anti-Alzheimer's disease activities -- Caenorhabditis elegans; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.07.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: A pair of new enantiomeric neoligans, (± )-neonardochinone A (1 ) were isolated from Nardostachys chinensis . The structure elucidation and chiral HPLC separation of (± )-neonardochinone A (1 ) were described. The absolute configurations of (–)-neonardochinone A and (+)-neonardochinone A were deduced by calculated ECD method. Compound 1 showed a possible significant anti-AD activity. Abstract: A pair of new enantiomeric neoligans, (± )-neonardochinone A (1 ) were isolated from Nardostachys chinensis . The structure of 1 was determined by extensive spectroscopic analysis, containing IR, HRESIMS, NMR spectra and single crystal X-ray diffraction. The enantiomeric separation was finished by HPLC on a chiral column. The absolute configurations were assigned via comparison of their calculated and experimental ECD data. The anti-Alzheimer's disease (AD) activities of 1, 1a, and 1b were also evaluated using the Caenorhabditis elegans AD pathological model, respectively, and 1 had the highest anti-AD activity.