1, 1, 1, 3, 3, 3-Hexafluoroisopropanol as an efficient medium for the room temperature oxidation of styrenes to benzaldehydes. Issue 46 (12th November 2020)

• Record Type: Journal Article
• Authors: Zhang, Zhuyong; Chen, Weidong; Luo, Junfei
• Is Part Of: Tetrahedron letters. Volume 61:Issue 46(2020)
• Publication Date: 2020-11-12
• Subjects: 1, 1, 1, 3, 3, 3-Hexafluoroisopropanol -- Mild conditions -- Oxidation -- Olefins -- Aldehydes; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152527
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Discovered a NHPI-catalyzed oxidation of styrenes to benzaldehyde derivatives. Practical convenience and highly functional group tolerance. Mild reaction conditions and low-cost reagents. Abstract: A room temperature N -hydroxyphthalimide-catalyzed oxidation of styrene derivatives to the corresponding aldehydes has been developed. The use of 1, 1, 1, 3, 3, 3-hexafluoroisopropanol as the solvent was determined as being key for efficient oxidation. The incorporated oxygen atom originates from molecular dioxygen.