Aggregate exposure modelling of vitamin A from cosmetic products, diet and food supplements. (September 2019)

• Record Type: Journal Article
• Authors: Tozer, Sarah; O'Mahony, Cian; Hannah, Jen; O'Brien, John; Kelly, Seamus; Kosemund-Meynen, Kirstin; Alexander-White, Camilla
• Is Part Of: Food and chemical toxicology. Volume 131(2019)
• Publication Date: 2019-09
• Subjects: Aggregate exposure -- Retinol equivalents -- Retinoic acid -- Cosmetics -- Consumer products -- Food -- Vitamin A; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.05.057
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Realism is important in estimating consumer exposure to a substance, especially when accounting for exposure from multiple sources. Humans are exposed to vitamin A from food, dietary supplements and cosmetics products. A probabilistic aggregate exposure model was developed for estimating exposure distributions to vitamin A (as retinol equivalents) in pre-/post-menopausal, and menopausal women in European and US populations. Data from large dietary surveys were used, together with realistic and extreme case scenarios of cosmetics product use (including occurrence data for vitamin A presence in 17 cosmetic products). Results of absorbed exposure estimates were expressed as μg/kg bw/day by incorporating dermal and oral bioavailability data. The mean and 95th percentile (P95) aggregate exposures were below the EU Tolerable Upper Intake Limit (3000 μg/day; 45 μg/kg/day internal exposure dose (IED)), providing positive assurances of safety. The major source of vitamin A exposure is the diet, with cosmetics providing only a small fraction of total exposure (2–5% at P95). In addition to providing a realistic assessment of total vitamin A exposure, this work provides a case study on how to approach future complex aggregate exposure questions. Highlights: Probabilistic aggregate exposure modelling of vitamin from cosmetics and diet. European and USA exposures to Vitamin A. Use of Crème modelling approaches to assessing aggregate exposure for cosmetics and foods exposure scenarios.