Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice. (September 2019)

• Record Type: Journal Article
• Authors: Yang, Meilian; Wu, Zihuan; Wang, Yudan; Kai, Guoyin; Singor Njateng, Guy Sedar; Cai, Shengbao; Cao, Jianxin; Cheng, Guiguang
• Is Part Of: Food and chemical toxicology. Volume 131(2019)
• Publication Date: 2019-09
• Subjects: Epigynum auritum -- Acute and subacute oral toxicities -- Hematology -- Histopathology -- Serum biochemistry analysis; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.05.042
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Acute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe. Graphical abstract: Image 1 Highlights: Acute & subacute toxicity of ethanol extract from aerial parts of Epigynum auritum (EAE) were assessed. The LD50 of EAE was higher than 5000 mg/kg BW evaluated by acute toxicity. EAE can be regarded as practically non-toxic based on acute toxicity. EAE didn't show toxicity at 312 mg/kg by subchronic toxicity. EAE showed toxicities to some organs at 1250 mg/kg and 2500 mg/kg.