White tea - A cost effective alternative to EGCG in fight against benzo(a)pyrene (BaP) induced lung toxicity in SD rats. (September 2019)

• Record Type: Journal Article
• Authors: Dhatwalia, Sunil Kumar; Kumar, Manoj; Bhardwaj, Priti; Dhawan, D.K.
• Is Part Of: Food and chemical toxicology. Volume 131(2019)
• Publication Date: 2019-09
• Subjects: Oxidative stress -- Lung tissue -- SD rats -- Endogenous oxidants; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.05.059
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Tea is a natural resource of catechins and exhibits antioxidative and anticancer activities. This study was designed to elucidate the comparative efficacy of white tea and pure EGCG in containing benzo (a) pyrene (BaP)-induced pulmonary stress. Rats were treated with white tea extract (WT) (1%) and pure EGCG at a dose of 80μg/ml in drinking water on alternate days for 12 weeks (4 weeks prior, during and after BaP treatment). BaP(50 mg/kg b. wt) was administered to rats orally in olive oil twice a week for four weeks. The indices such as stress biomarkers (LPO, PCC & ROS), antioxidant enzymes (SOD, CAT, GSH, GST, GR, GPx) activities and lung histoarchitecture were assessed. BaP administration enhanced the levels of inflammatory markers (NO and citrulline) and reduced activities of antioxidant enzymes. We observed similar antioxidant efficacy by both WT and EGCG as seen by their ameliorative action in restoring BaP induced oxidative and inflammatory stress as well as lung histoarchitecture. Our findings suggest that WT is equally beneficial as EGCG in maintaining the integrity of alveoli and is a potential candidate to be used as a cost effective and protective agent in conditions of BaP-induced lung damage. Highlights: White Tea (WT) is rich in antioxidants including EGCG and the investigations exhibited its potential protective role in containing benzo(a)pyrene (BaP) induced lung toxicity in Sprague Dawley rats. Both WT and EGCG showed effectiveness in quelling BaP induced adverse effects on various biochemical indices. The present study did not reveal any appreciable difference in the effectiveness exerted by both White Tea and EGCG on various biochemical, morphological and structural indices.