Annotation matters: validating the discovery of cancer drivers. (1st November 2020)

• Record Type: Journal Article
• Authors: Rodríguez-Martínez, Marta; Svejstrup, Jesper Q.
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 6(2020)
• Publication Date: 2020-11-01
• Subjects: STK19 -- annotation -- cancer driver -- kinase; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2020.1806679
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Advanced sequencing techniques have helped unveil numerous new, potential cancer driver mutations. However, manual curation and analysis of gene and protein annotation are essential to verify such discoveries. Our recent study of STK19 (Serine Threonine Kinase 19), a previously identified melanoma driver, is a clear example of the importance of such detailed analysis, with both STK19 gene and protein annotations in frequently used databases having been proven incorrect.