A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers. (November 2020)

• Record Type: Journal Article
• Authors: Dumont, Frédéric; Passot, Christophe; Raoul, Jean-Luc; Kepenekian, Vahan; Lelièvre, Bénédicte; Boisdron-Celle, Michelle; Hiret, Sandrine; Senellart, Hélène; Pein, Francois; Blanc-Lapierre, Audrey; Raimbourg, Judith; Thibaudeau, Emilie; Glehen, Olivier
• Is Part Of: European journal of cancer. Volume 140(2020)
• Page Start: 37
• Page End: 44
• Publication Date: 2020-11
• Subjects: Peritoneal carcinomatosis -- Gastrointestinal carcinoma -- PIPAC -- Oxaliplatin; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2020.09.010
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Objective: The objectives were to define the maximum tolerated dose (MTD), safety profile and pharmacokinetics (PKs) of intraperitoneal oxaliplatin delivered by pressurised intraperitoneal aerosol chemotherapy (PIPAC) in patients with advanced peritoneal carcinomatosis from gastrointestinal tract cancers. Methods: PIPAC was applied every 4–6 weeks, for 5 cycles, in a phase I dose-escalation study using a 3 + 3 design. The first dose level was 90 mg/m 2 with planned increases of 50 mg/m 2 per level. Platinum concentration was measured in plasma, tissues and intraperitoneal fluid samples. The trial was registered at ClinicalTrials.gov (NCT03294252 ). Results: Ten patients with 33 PIPAC sessions were included. No dose limiting toxicity (DLT) occurred at 90 mg/m 2 and two at 140 mg/m 2 . The MTD was therefore set at 90 mg/m 2 . Overall treatment included a median number of three PIPAC sessions (range: 1–5) and secondary complete cytoreductive surgery for two patients. Overall safety showed 67 grade I–II and 11 grade III–IV toxicities, usually haematologic, digestive (nausea/vomiting, abdominal pain), and fatigue. Oxaliplatin concentrations were three- to four-fold higher in tissue in contact with aerosol than in muscle without contact. At 140 mg/m 2, the plasma oxaliplatin concentration was high with Cmax and area under the curve (AUC)0–48h of 1035 μg/l and 9028 μg h/L, respectively. Conclusions: The MTD of oxaliplatin during PIPAC is 90 mg/m 2 . PK data demonstrate a high tumour concentration and a significant systemic absorption. Highlights: The maximal dose of oxaliplatin during intraperitoneal aerosol is 90 mg/m 2 . The median number of feasible PIPAC is three. Some patients with major histological responses underwent a complete resection. Platin concentrations are three- to four-fold higher in tumour than in muscle. The systemic absorption of oxaliplatin is high.