Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial. Issue 11 (November 2020)

• Record Type: Journal Article
• Authors: Khoury, David S.; Cao, Pengxing; Zaloumis, Sophie G.; Davenport, Miles P.
• Is Part Of: Trends in parasitology. Volume 36:Issue 11(2020)
• Page Start: 884
• Page End: 887
• Publication Date: 2020-11
• Subjects: malaria -- drug resistance -- artemisinin -- selection pressure; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2020.07.004
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract : Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.