Efficacy of a hospital policy of selective digestive decontamination for carbapenem-resistant Enterobacterales carriers: prospective before–after study. Issue 3 (November 2020)

• Record Type: Journal Article
• Authors: Bar-Yoseph, H.; Lulu, C.; Shklar, S.; Korytny, A.; Even Dar, R.; Daoud, H.; Hussein, K.; Bar-Lavie, Y.; Jabareen, A.; Geffen, Y.; Paul, M.
• Is Part Of: Journal of hospital infection. Volume 106:Issue 3(2020)
• Page Start: 495
• Page End: 499
• Publication Date: 2020-11
• Subjects: Carbapenem-resistant Enterobacterales -- Multi-drug-resistant bacteria -- Carriers -- Selective digestive decontamination -- Eradication; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2020.08.007
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: A single-centre interrupted time series quasi-experimental study was undertaken to assess whether a hospital policy of selective digestive decontamination (SDD, gentamicin/amikacin with neomycin) administered to carbapenem-resistant Enterobacterales (CRE) carriers would reduce the duration of carriage and contain the spread of CRE. No significant difference in time to CRE eradication was observed between the observation (12 months, 120 patients) and intervention (12 months, 101 patients) periods. No change in the trend of new in-hospital CRE acquisitions or bacteraemia during the intervention was detected. As such, administration of SDD to CRE carriers was not effective for the eradication of carriage or controlling in-hospital CRE transmissions.