Association of maternal dietary intakes and CBS gene polymorphisms with congenital heart disease in offspring. (1st January 2021)

• Record Type: Journal Article
• Authors: Li, Yihuan; Diao, Jingyi; Li, Jinqi; Luo, Liu; Zhao, Lijuan; Zhang, Senmao; Wang, Tingting; Chen, Letao; Yang, Tubao; Chen, Lizhang; Zhu, Ping; Qin, Jiabi
• Is Part Of: International journal of cardiology. Volume 322(2021)
• Page Start: 121
• Page End: 128
• Publication Date: 2021-01-01
• Subjects: Congenital heart disease -- Cystathionine beta-synthase gene -- Dietary intakes -- Case-control study -- Interaction effects; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2020.08.018
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Although it is generally acknowledged that genetic and environmental factors are associated with risk of congenital heart disease (CHD), the causes are not fully understood. This study aimed at assessing the association of maternal dietary intakes, genetic variants of cystathionine beta synthase (CBS) gene and their interactions with risk of CHDs in offspring. Method: A hospital-based case-control study of 464 mothers with CHD infants and 504 control mothers of health infant was performed. The exposures of interest were maternal dietary intakes in early pregnancy, single nucleotide polymorphisms (SNPs) of CBS gene. Results: More frequent intake of pickled vegetables (adjusted odds ratio[aOR] = 1.81; 95% confidence interval[CI]: 1.38–2.37), smoked foods (aOR = 2.00; 95%CI: 1.53–2.60), barbecued foods (aOR = 1.63; 95%CI: 1.19–2.25) and fried foods (aOR = 1.57; 95%CI: 1.22–2.03) were associated with higher risk of CHD, while salted eggs (aOR = 0.20; 95%CI: 0.12–0.33), fish and shrimp (aOR = 0.34; 95%CI: 0.27–0.44), fresh fruits (aOR = 0.49; 95%CI: 0.37–0.66), and milk products (aOR = 0.54; 95%CI: 0.45–0.65) were associated with lower risk of CHD. The SNPs of CBS gene at rs2851391 (T/T vs C/C: aOR = 1.91, 95%CI: 1.15–3.15) and rs234714 (T/T vs C/C: aOR = 2.22, 95%CI: 1.32–3.73) significantly increased the risk of CHD. Additionally, significant interaction effects between maternal dietary intakes and CBS genetic variants on CHD risks were observed. Conclusions: Maternal dietary factors, CBS genetic variants and their interactions were significantly associated with risk of CHD in offspring. However, it is still unclear how these factors jointly work in the development of CHD, and more studies with larger samples and prospective design are required. Highlights: Maternal dietary factors in early pregnancy are significantly associated with the development of CHD in offspring. The polymorphisms of CBS gene at rs2851391 and rs234714 significantly increase the risk of CHD in offspring. There are Interaction effects between maternal dietary intakes and polymorphisms of the CBS gene on the risk of CHD.