Hemorrhagic, thrombotic and obstetric complications of congenital dysfibrinogenemia in a previously asymptomatic woman. Issue 196 (December 2020)

• Record Type: Journal Article
• Authors: Peterson, Wynn; Liederman, Zachary; Baker, Jillian; Floros, Georgina; Martin, Rachel; Berger, Howard; Meffe, Filomena; Teitel, Jerry; Sholzberg, Michelle
• Is Part Of: Thrombosis research. Issue 196(2020)
• Page Start: 127
• Page End: 129
• Publication Date: 2020-12
• Subjects: Decision-making -- Dysfibrinogenemia, congenital -- Hemorrhage -- Placental insufficiency -- Pregnancy -- Thrombosis; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2020.08.028
• Languages: English
• ISSNs: 0049-3848

Abstract

Highlights: Dysfibrinogenemia is a highly heterogeneous disorder. Clinical manifestations can vary across successive pregnancies. In vitro fibrinogen activity at delivery is weakly correlated with clinical outcomes. Fibrinogen replacement may fail to improve in vitro fibrinogen activity. An individualized approach to management of dysfibrinogenemia in pregnancy is required.