A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish. Issue 91 (27th October 2020)

• Record Type: Journal Article
• Authors: Guo, Zhenbo; Wang, Mei; Li, Xueyan; Jia, Xu; Wang, Xiaoli; Zhang, Pingzhu; Wei, Chao; Li, Xiaoliu
• Is Part Of: Chemical communications. Volume 56:Issue 91(2020)
• Page Start: 14183
• Page End: 14186
• Publication Date: 2020-10-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05330a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel hepatocyte-targeting fluorescent N2 H4 probe was first prepared. The probe can be used to image N2 H4 produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ . Abstract : A hepatocyte-targeting fluorescent N2 H4 probe, GHP, was first designed and synthesized employing N -acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image N2 H4 produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ .