NCS-promoted thiocyanation and selenocyanation of pyrrolo[1, 2-a]quinoxalines. Issue 44 (4th November 2020)

• Record Type: Journal Article
• Authors: Yang, Zhen; He, Jing; Wei, Yueting; Li, Weiwei; Liu, Ping; Zhao, Jixing; Wei, Yu
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 44(2020)
• Page Start: 9088
• Page End: 9094
• Publication Date: 2020-11-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01818j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient NCS-promoted thiocyanation of pyrrolo[1, 2- a ]quinoxalines with NH4 SCN or KSCN was developed. Moreover, in the presence of KSeCN, the selenocyanation of pyrrolo[1, 2- a ]quinoxalines was also achieved. Abstract : An efficient NCS-promoted thiocyanation of pyrrolo[1, 2- a ]quinoxalines with NH4 SCN or KSCN is described. A series of diverse 1-thiocyanatopyrrolo[1, 2- a ]quinoxalines were obtained in good yields with excellent functional group tolerance. With a similar strategy, the selenocyanation of pyrrolo[1, 2- a ]quinoxalines with KSeCN is also achieved. Importantly, this approach features mild reaction conditions, broad substrate scope, and gram-scale synthesis. Moreover, the transformations of the products are also further examined.