A facile access to N-sulfonylthioimidates and their use for the transformation to 3, 4-dihydroquinazolines. Issue 43 (27th October 2020)

• Record Type: Journal Article
• Authors: Wu, Jia-Yu; Liao, Wei-Jr; Lin, Xiu-Yi; Liang, Chien-Fu
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 43(2020)
• Page Start: 8881
• Page End: 8885
• Publication Date: 2020-10-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01963a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : N -sulfonylthioimidates can be synthesized via terminal alkynes, sulfonyl azide, and thiols using a copper catalyst in the presence of 4-dimethylaminopyridine. Subsequently, it can be transformed to crucial pharmacophores of 3, 4-dihydroquinazoline. Abstract : N -Sulfonylthioimidates can be efficiently synthesized through one-pot three-component coupling of terminal alkynes, sulfonyl azides, and thiols by using a copper(i ) catalyst in the presence of 4-dimethylaminopyridine. The proposed reaction is characterized by mild reaction conditions and tolerance of diverse functional groups. Additionally, the crucial pharmacophore of 3, 4-dihydroquinazolines was synthesized using a one-pot synthetic strategy from N -sulfonylthioimidates.