Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper. Issue 90 (23rd October 2020)

• Record Type: Journal Article
• Authors: Terashima, Norikazu; Sakata, Yuki; Meguro, Tomohiro; Hosoya, Takamitsu; Yoshida, Suguru
• Is Part Of: Chemical communications. Volume 56:Issue 90(2020)
• Page Start: 14003
• Page End: 14006
• Publication Date: 2020-10-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc06551j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient preparation of functionalized phosphines by triazole formation through the transient protection of phosphine from the Staudinger reaction is disclosed. Double- and triple-click assemblies of azides were accomplished. Abstract : An efficient preparation method of functionalized phosphines by copper-catalyzed azide–alkyne cycloaddition (CuAAC) through the transient protection of phosphine from the Staudinger reaction is disclosed. Diverse phosphines were prepared from phosphinyl alkynes and azides by the click reaction at the ethynyl group without damaging the phosphinyl group. Double- and triple-click assemblies of azides were accomplished by triazole formations and robust azaylide formation.