RAS variant signalling. (4th October 2018)

• Record Type: Journal Article
• Authors: Mo, Stephanie P.; Coulson, Judy M.; Prior, Ian A.
• Is Part Of: Biochemical Society transactions. Volume 46:Number 5(2018)
• Page Start: 1325
• Page End: 1332
• Publication Date: 2018-10-04
• Subjects: cancer -- codon -- isoforms -- mutation -- RAS -- signalling; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20180173
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent findings describing how RAS isoforms and different activating mutations differentially contribute to normal and disease-associated biology and the mechanisms that have been proposed to underpin this.