Paradoxical Early Increase in Prostate-Specific Membrane Antigen Uptake Following Cryoablation for Local Recurrence After Radical Prostatectomy. (July 2019)

• Record Type: Journal Article
• Authors: Mariotti, Guilherme Cayres; Cunha, Marcelo Livorsi; Carneiro, Arie; Smaletz, Oren; Baroni, Ronaldo Hueb; Garcia, Rodrigo Gobbo
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 7(2019)
• Publication Date: 2019-07
• Subjects: 68Ga-PSMA PET/CT -- cryoablation -- interventional radiology -- prostatic neoplasms/diagnosis; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002604
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We report a case of a 43-year-old man who underwent a radical prostatectomy 3 years before the procedure (June 2015) for a locally advanced Gleason 7(4 + 3) prostate adenocarcinoma (pT3aN0), with negative surgical margins, followed by salvage radiotherapy. He also underwent antiandrogen therapy for biochemical relapse (bicalutamide) from October 2016 through May 2017, but prostate-specific antigen continued to rise (2.5 ng/mL [December 2017] and 3.3 ng/mL [February 2018]). At this point, he underwent a 68 Ga–prostate-specific membrane antigen PET/CT, and after multidisciplinary discussion, the therapeutic option chosen was image-guided salvage cryoablation.