Effects of exercise on residual renal function in patients undergoing peritoneal dialysis: A post‐hoc analysis of a randomized controlled trial. Issue 6 (7th March 2020)

• Record Type: Journal Article
• Authors: Uchiyama, Kiyotaka; Washida, Naoki; Morimoto, Kohkichi; Muraoka, Kaori; Nakayama, Takashin; Adachi, Keika; Kasai, Takahiro; Miyashita, Kazutoshi; Wakino, Shu; Itoh, Hiroshi
• Is Part Of: Therapeutic apheresis and dialysis. Volume 24:Issue 6(2020)
• Page Start: 668
• Page End: 676
• Publication Date: 2020-03-07
• Subjects: exercise -- liver‐type fatty acid‐binding protein -- microalbumin‐to‐creatinine ratio -- peritoneal dialysis -- residual renal function; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.13481
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: We aimed to investigate the effects of exercise on renal outcomes in patients undergoing peritoneal dialysis (PD). In a post‐hoc analysis of a randomized controlled trial of a 12‐week home‐based exercise program involving 47 patients undergoing PD, we excluded 18 patients with anuria and analyzed 13 and 16 patients in the usual care and exercise groups, respectively. The primary outcomes were weekly renal creatinine clearance (CCr) and urinary biomarkers: liver‐type fatty acid‐binding protein (L‐FABP) and the microalbumin‐to‐creatinine ratio (ACR). Although the maintenance of weekly renal CCr in the exercise group was not significantly different compared with that in the usual care group ( P = .09), urinary L‐FABP levels ( P = .02) and ACR ( P = .04) were significantly decreased in the exercise group. To the best of our knowledge, this is the first study to demonstrate the beneficial effects of exercise on renal outcomes in patients undergoing PD.