Minimized perfusion circuit for acute type A aortic dissection surgery. Issue 11 (7th June 2020)

• Record Type: Journal Article
• Authors: Kimura, Naoyuki; Momose, Naoki; Kusadokoro, Sho; Yasuda, Toru; Kusaura, Rie; Kokubo, Ryo; Hori, Daijiro; Okamura, Homare; Itoh, Satoshi; Yuri, Koichi; Yamaguchi, Atsushi
• Is Part Of: Artificial organs. Volume 44:Issue 11(2020)
• Page Start: E470
• Page End: E481
• Publication Date: 2020-06-07
• Subjects: aortic dissection -- minimized perfusion circuit -- transfusion; Artificial organs -- Periodicals; 617.956
• DOI: 10.1111/aor.13724
• Languages: English
• ISSNs: 0160-564X

Abstract

Abstract: A minimized perfusion circuit (MPC) may reduce transfusion requirement and inflammatory response. Its use, however, has not been standardized for complicated cardiovascular surgery. We assessed outcomes of surgery for acute type A aortic dissection (ATAAD) performed with a MPC under circulatory arrest. The study involved 706 patients treated surgically for ATAAD (by hemiarch repair [n = 571] or total arch repair [n = 135]). Total arch repair was performed using selective antegrade cerebral perfusion. Our MPC, a semi‐closed bypass system, incorporating a completely closed circuit and a level‐sensing reservoir in the venous circuit, was used. Clinical variables, transfusion volume, and outcomes were investigated in patients who underwent hemiarch repair or total arch repair. The overall incidences of shock, organ ischemia, and coagulopathy (prothrombin time–international normalized ratio >1.5) were 26%, 35%, and 8%, respectively. Mean extracorporeal circulation (ECC) time was 149 minutes for the hemiarch repair group and 241 minutes for the total arch repair group, respectively. No patient required conversion to conventional ECC, and there were no complications related to the use of the MPC. The need for transfusion (98% vs. 91%, P = .017) and median transfusion volume (1970 vs. 1680 mL, P = .002) was increased in the total arch repair group. Neither in‐hospital mortality (total arch; 12% vs. hemiarch; 7%, P = .11) nor 10‐year survival (74.4% vs. 68.4%, P = .79) differed significantly. Outcomes of surgery for ATAAD performed with the MPC were acceptable. The possibility of transfusion and transfusion volume remains high during such surgery, despite the use of the MPC.