Applications of benchtop NMR in the organic chemistry instructional laboratory. (21st June 2020)

• Record Type: Journal Article
• Authors: Morrison, Richard W.; Zhang, Mengqi
• Other Names: Riegel Susanne D. guestEditor.; Bell Nicholle G.A. guestEditor.
• Is Part Of: Magnetic resonance in chemistry. Volume 58:Number 12(2020)
• Page Start: 1187
• Page End: 1192
• Publication Date: 2020-06-21
• Subjects: Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.5031
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract: The instructional organic chemistry laboratory has been substantially improved through the implementation of benchtop NMR analysis. When used in conjunction with unknown reaction components in multi‐outcome experiments, NMR analysis transforms the laboratory exercise into an investigative inquiry wherein students elucidate structures for their products and thereby deduce their unknown reaction components. This analytical approach closely models the research laboratory and is a valuable preparatory tool for undergraduate researchers. Three newly developed multi‐outcome experiments based upon the Diels–Alder cycloaddition, the synthesis of carboxylic amides, and the Friedel‐Crafts alkylation are herein described to illustrate the utility of benchtop NMR analysis in the instructional laboratory. Abstract : The instructional organic chemistry laboratory is substantially improved through the implementation of benchtop NMR analysis. When used in conjunction with unknown reaction components in multi‐outcome experiments, NMR analysis transforms the laboratory exercise into an investigative inquiry wherein students elucidate structures for their products and thereby deduce unknown reaction components. This analytical approach closely models the research laboratory and is a valuable preparatory tool for undergraduate researchers. Three newly developed experiments for the instructional laboratory illustrate the utility of benchtop NMR.