A simple and efficient route to 2‐arylimidazo[1, 2‐a]pyridines and zolimidine using automated grindstone chemistry. (7th September 2020)

• Record Type: Journal Article
• Authors: Das, Dharmendra; Bhutia, Zigmee T.; Panjikar, Padmini C.; Chatterjee, Amrita; Banerjee, Mainak
• Is Part Of: Journal of heterocyclic chemistry. Volume 57:Number 11(2020)
• Page Start: 4099
• Page End: 4107
• Publication Date: 2020-09-07
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4106
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: A green and efficient mechanochemical method for the synthesis of a series of 2‐arylimidazo[1, 2‐a]pyridines was developed using an electrical grinder. I2 catalyzed mechanochemical grinding facilitates the cyclocondensation reaction between various aryl methyl ketones and 2‐aminopyridines to afford 2‐arylimidazo[1, 2‐a]pyridines in good yields at ambient temperature. The method was successfully used for the gram‐scale synthesis of a marketed drug, zolimidine. The noticeable advantages of this environmentally sustainable protocol include mild conditions, simple instrumentation, inexpensive catalyst, atom economy, short reaction time etc. Abstract :