Ultrasmall Ternary FePtMn Nanocrystals with Acidity‐Triggered Dual‐Ions Release and Hypoxia Relief for Multimodal Synergistic Chemodynamic/Photodynamic/Photothermal Cancer Therapy. Issue 21 (21st September 2020)

• Record Type: Journal Article
• Authors: Yang, Baochan; Dai, Zhichao; Zhang, Gaorui; Hu, Zunfu; Yao, Xiuxiu; Wang, Shan; Liu, Qingyun; Zheng, Xiuwen
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 21(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-21
• Subjects: dual‐ROS generation -- multimodal imaging -- photothermal effects -- synergistic cancer therapy -- ternary FePtMn nanocrystals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201901634
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Multimodal imaging‐guided synergistic anticancer strategies have attracted increasing attention for efficient diagnosis and therapy of cancer. Herein, a multifunctional nanotheranostic agent FePtMn‐Ce6/FA (FPMCF NPs) is constructed by covalently anchoring photosensitizer chlorin e6 (Ce6) and targeting molecule folic acid (FA) on ultrasmall homogeneous ternary FePtMn nanocrystals. Response to tumor microenvironment (TME), FPMCF NPs can release Fe 2+ to catalyze H2 O2 into OH by Fenton reaction and simultaneously catalyze hydrogen peroxide (H2 O2 ) into O2 to overcome the tumor hypoxia barrier. Released O2 is further catalyzed into 1 O2 under 660 nm laser irradiation with Ce6. Thus, the FPMCF NPs exhibit superior dual‐ROS oxidization capability including ferroptosis chemodynamic oxidization and 1 O2 ‐based photodynamic oxidization. Interestingly, FPMCF NPs reveal strong photothermal conversion efficiency exposed to an 808 nm laser, which can assist dual‐ROS oxidization to suppress solid tumor remarkably. Additionally, Mn 2+ can be released from FPMCF NPs to enhance longitudinal relaxivity (T1 ‐weighted magnetic resonance (MR) imaging) and Fe‐synergistic transverse relaxivity (T2 ‐weighted MR imaging), which is convenient for diagnosis of solid tumors. Meanwhile, the fluorescent/photothermal (FL/PT) imaging function of FPMCF NPs can also accurately monitor tumor location. Therefore, FPMCF NPs with multimodal MR/FL/PT imaging‐guided synergistic chemodynamic/photodynamic/photothermal cancer therapy capability have potential bioapplication in bionanomedicine field. Abstract : A multifunctional nanotheranostic agent FePtMn‐Ce6/FA (FPMCF NPs) is constructed with ultrasmall homogeneous ternary FePtMn nanocrystals for cancer therapy. The FPMCF NPs exhibit tumor microenvironment‐dependent dual‐reactive oxygen species oxidization behavior and strong photothermal conversion efficiency when exposed to 808 nm laser irradiation. Therefore, FPMCF NPs with remarkable synergistic chemodynamic/photodynamic/photothermal cancer therapy effect have potential bioapplication in bionanomedicine field.