Temperature Feedback‐Controlled Photothermal/Photodynamic/Chemodynamic Combination Cancer Therapy Based on NaGdF4:Er, Yb@NaGdF4:Nd@Cu‐BIF Nanoassemblies. Issue 21 (1st October 2020)

• Record Type: Journal Article
• Authors: Qi, Ye; Ye, Junwei; Ren, Shuangsong; Wang, Guangyao; Lv, Jialin; Zhang, Siqi; Che, Ying; Li, Yachen; Chen, Baojiu; Ning, Guiling
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 21(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-01
• Subjects: ablation mechanisms -- anticancer therapies -- combination therapy -- temperature feedback -- theranostic nanoplatforms; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202001205
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The intelligent design of multifunctional nanoplatforms is critical for cancer therapy. Herein, NaGdF4 :Er, Yb@NaGdF4 :Nd@Cu(II) boron−imidazolate frameworks (denoted as CSNPs@Cu‐BIF) nanoassemblies are designed and fabricated. Upon a single 808 nm laser irradiation, the nanoassemblies not only show the outstanding photothermal conversion capacity ( η = 41.7%) but also generate cytotoxic reactive oxygen species through an in situ Fenton‐like reaction and fluorescence resonance energy transfer. Importantly, the nanoassemblies simultaneously introduce remarkable antitumor efficacy via photothermal/photodynamic/chemodynamic combination therapy both in vitro and in vivo. To improve the therapeutic effect of solid tumor ablation, it is highly desirable to monitor the treatment process in real‐time. Multiclinical imaging modalities of ultrasonography are employed to systematically investigate the ablation mechanism of solid tumors in vivo. Furthermore, the significant difference between the eigen temperature of CSNPs@Cu‐BIF nanoassemblies obtained by the temperature‐sensitive emission bands signal changes and the apparent temperature recorded by the thermal imaging camera is 14.55 K at equilibrium. This current work therefore supplies an alternative strategy in temperature feedback‐controlled accurate cancer therapy. Abstract : As‐synthesized NaGdF4 :Er, Yb@NaGdF4 :Nd@Cu(II) boron−imidazolate frameworks nanoassemblies can simultaneously increase the temperature and generate reactive oxygen species under 808 nm laser irradiation, achieving the synergistic effect of photothermal/photodynamic/chemodynamic, which is proven to realize excellent antitumor outcomes.