Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review. Issue 6 (16th May 2020)

• Record Type: Journal Article
• Authors: Kawasaki, Eiji; Fukuyama, Takahiro; Kuriyama, Erisa; Uchida, Aira; Sagara, Yoko; Tamai, Hidekazu; Nakano, Yuko; Tojikubo, Masayuki; Koga, Nobuhiko
• Is Part Of: Journal of diabetes investigation. Volume 11:Issue 6(2020)
• Page Start: 1673
• Page End: 1676
• Publication Date: 2020-05-16
• Subjects: Autoimmune hepatitis -- Statins -- Type 1 diabetes; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13271
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6 months into atorvastatin therapy. The second patient developed liver dysfunction 8 months after the initiation of rosuvastatin therapy. Liver biopsies in both patients showed either portal, interface and lobular hepatitis or a piece‐meal necrosis with lymphocytes and plasma cell infiltration that were compatible with autoimmune hepatitis. Then, both patients were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type 1 diabetes patients if there is no improvement of liver dysfunction after discontinuation of statins. Abstract : Statins are a widely used drug for the treatment of hypercholesterolemia, as well as prevention of the onset of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin.