Kryptoracemic compound hunting and frequency in the Cambridge Structural Database. Issue 43 (3rd July 2020)

• Record Type: Journal Article
• Authors: Clevers, Simon; Coquerel, Gérard
• Is Part Of: CrystEngComm. Volume 22:Issue 43(2020)
• Page Start: 7407
• Page End: 7419
• Publication Date: 2020-07-03
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/d0ce00303d
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Determination of kryptoracemic compound frequency in the Cambridge Structural Database using CCDC Python API script. Abstract : Kryptoracemic compounds (KRCs) are a rare case of racemic pairs of antipodes crystallizing in Sohncke (chiral) space groups. In order to identify KRCs in the Cambridge Crystallographic Structural Database (CSD), a Python script named ChiPi was written to automatically assign the chirality of each crystal structure. The ChiPi code is able to compare each residue contained in a crystal structure based on the chiral centres that were identified and allows discrimination between enantiomeric, diastereomeric, racemic, meso and scalemic structures. It was used to process 393 012 organic entries from the CSD corresponding to almost the entire set of organic crystal structures. It is estimated that racemic compounds constitute 23.8% and 22.2% of centrosymmetric and achiral non-centrosymmetric organic structures in the CSD, respectively. The KRCs represent 0.2% of the whole database and 0.8% of the chiral space groups. The KRC occurrence represents circa 1% (724 structures) of the set of racemic compounds. The distribution of the KRC space groups is drastically shifted toward lower symmetry space groups with a large prevalence of P 21 structures. This trend is not restricted to KRCs only but can be extended to structures containing chiral molecules with an even Z ′ number.