Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts. Issue 11 (5th October 2020)

• Record Type: Journal Article
• Authors: Hwang, Jangsun; Zheng, Mengjia; Wiraja, Christian; Cui, Mingyue; Yang, Lixia; Xu, Chenjie
• Is Part Of: Nanoscale advances. Volume 2:Issue 11(2020)
• Page Start: 5254
• Page End: 5262
• Publication Date: 2020-10-05
• Subjects: 620.5
• DOI: 10.1039/d0na00572j
• Languages: English
• ISSNs: 2516-0230

Abstract

Abstract : This study reports the synthesis of nanoghosts for reprogramming M0 macrophages to the M2 type. They are non-toxic, execute reprogramming through surface-bound cytokines/chemokines, and could help the wound healing process by stimulating M2 conversion. Abstract : Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.