Manganese- and rhenium-catalyzed C–H enaminylation: expedient access to novel indole–purine hybrids with anti-tumor bioactivities. Issue 22 (26th October 2020)

• Record Type: Journal Article
• Authors: Xu, Zhongnan; Wang, Yuqing; Zheng, Yucheng; Huang, Zhixing; Ackermann, Lutz; Ruan, Zhixiong
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 22(2020)
• Page Start: 3709
• Page End: 3714
• Publication Date: 2020-10-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01120g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The C–H enaminylation of novel 6-(1 H -indol-1-yl)-purines with ketenimines was accomplished by means of aqueous manganese and rhenium catalysis, which sets the stage for the facile synthesis of indole–purine hybrids with anti-tumor bioactivities. Abstract : The C–H enaminylation of novel 6-(1 H -indol-1-yl)-purines with ketenimines was accomplished by means of eco-friendly aqueous manganese catalysis as well as rhenium catalysis with low catalyst loading. The versatile C–H enaminylation features unparalleled broad substrate scope with good yields, and high levels of chemo-, site- and regio-selectivity. The well-defined organometallic C–H functionalization sets the stage for the facile synthesis of indole–purine hybrids with anti-tumor bioactivities.