Oxygen self-enriched single-component "black carbon nitride" for near-infrared phototheranostics. Issue 42 (26th October 2020)

• Record Type: Journal Article
• Authors: Huang, Yuxin; Tian, Yanan; Shu, Jie; Wang, Fu; Wei, Xunbin
• Is Part Of: Nanoscale. Volume 12:Issue 42(2020)
• Page Start: 21812
• Page End: 21820
• Publication Date: 2020-10-26
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr05871h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Single component agent-based near-infrared phototheranostics has captivated researchers in cancer treatment over recent decades. Abstract : Single component agent-based near-infrared phototheranostics has captivated researchers in cancer treatment over recent decades. However, the current single-component agents rarely alleviate the hypoxic microenvironment in tumor cells, which severely limits the development of photodynamic therapy. Here, we report a new phototheranostic agent, single-component black graphite carbon nitride nanoparticles (named CN-B NPs), synthesized through thermal copolymerization. Compared with unmodified graphitic carbon nitride (g-C3 N4 ), the absorption of CN-B NPs in the near-infrared region was enhanced. Through in vitro and in vivo studies, we demonstrated that CN-B NPs can be used as a near-infrared phototheranostic agent in both normoxia and hypoxia, simultaneously allowing infrared thermal/photoacoustic imaging and photodynamic/photothermal co-therapy, thereby resulting in remarkable inhibition of tumor growth. This approach could provide a new method to achieve multimodal phototheranostics using a single-component material.