The Impact of Cardiac-induced Post-traumatic Stress Disorder Symptoms on Cardiovascular Outcomes: Design and Rationale of the Prospective Observational Reactions to Acute Care and Hospitalizations (ReACH) Study. (14th January 2019)

• Record Type: Journal Article
• Authors: Birk, Jeffrey; Kronish, Ian; Chang, Bernard; Cornelius, Talea; Abdalla, Marwah; Schwartz, Joseph; Duer-Hefele, Joan; Sullivan, Alexandra; Edmondson, Donald
• Is Part Of: Health psychology bulletin. Volume 3(2019)
• Page Start: 10
• Page End: 20
• Publication Date: 2019-01-14
• Subjects: acute coronary syndrome -- posttraumatic stress disorder -- cardiovascular disease -- emergency department -- psychosocial factors -- medication adherence
• DOI: 10.5334/hpb.16
• Languages: English
• ISSNs: 2398-5941

Abstract

Aims: As many as 1 in 8 acute coronary syndrome (ACS) patients develop posttraumatic stress disorder (PTSD ) due to the ACS, and ACS-induced PTSD may increase secondary cardiovascular disease (CVD) risk. However, prior studies have been small and underpowered to test plausible behavioral or biological mechanisms of the hypothesized PTSD-secondary CVD risk association. In this paper, we describe the design and methods of a large prospective observational cohort study to estimate the prognostic significance of ACS-induced PTSD, mechanisms for its association with CVD risk, and emergency department (ED) factors that may increase PTSD risk, in a cohort of patients evaluated for acute coronary syndrome (ACS) in the ED of a large, urban academic medical center. Methods: The Reactions to Acute Care and Hospitalization (ReACH) study follows 1, 741 racially, ethnically, and socioeconomically diverse patients initially presenting to the ED with ACS symptoms. Psychosocial factors are assessed at baseline. Medication adherence is monitored by electronic pill bottle (eCAP). Participants are contacted by phone at 1-, 6-, and 12-months post-hospitalization to assess PTSD symptoms, hospital readmission, and recurrent CVD events/mortality (proactively searched and confirmed by medical records). Conclusion: This study will provide the most accurate estimates to date of PTSD's association with recurrent CVD events and mortality and will test whether medication adherence mediates that association. Further, it will provide estimates of the contribution of ED and hospital factors to PTSD risk in ACS patients. If our hypotheses are supported, we will have identified PTSD as a novel target for secondary risk reduction.